ALLO-715: Exploring Gamma Secretase Inhibition (GSI) in Multiple Myeloma

Potential increase in antitumor efficacy

• Nirogacestat increases B cell maturation antigen (BCMA) expression in MM cell lines¹​
• Others have shown that GSI may increase the antitumor efficacy of autologous BCMA-directed CAR T therapy²

¹Data on File. Allogene Therapeutics.​
²Blood. 2019;134(19):1585-1597. doi:10.1182/blood.2019000050